Biotin and derivatives
Medchemexpress LLC Biotin-azide (N-(3-Azidopropyl)biotinamide) | 908007-17-0 | 99.8% | 25 MG
Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group. It can be used to prepare various biotinylated conjugates via Click Chemistry. It is a click chemistry reagent, containing an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- A form of biotin with a terminal azide group.
- Can be used to prepare various biotinylated conjugates via click chemistry.
- Contains an azide group for copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups.
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29 | 10 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups separated by a PEG21 spacer. It is supplied as a high-purity reagent for bioconjugation, PROTAC synthesis, and antibody-drug conjugate construction.
- Two NHS ester reactive groups for amine coupling.
- PEG21 spacer provides hydrophilicity and flexibility.
- High purity suitable for conjugation chemistry applications.
- Intended for PROTAC and ADC linker development and general PEGylation chemistry.
- Available in small-scale quantities for research use.
Medchemexpress LLC DBCO-NHS ester | 1353016-71-3 | 99.1% | 402.40 g·mol⁻1 | C23H18N2O5 | 5 MG
DBCO-NHS ester is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester for copper-free click bioconjugation via strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to install linkers and conjugate azide-bearing molecules in chemical biology and antibody-drug conjugate (ADC) workflows.
- Enables copper-free SPAAC with azide-containing molecules.
- Suitable for linker installation and bioconjugation in ADC and biomolecule conjugation workflows.
- Reported high purity for analytical and preparative use.
- Available in small research quantities, including 5 MG format.
Medchemexpress LLC DBCO-NHS ester 3 50mg | 1393350-27-0 | 416.43 g/mol | C24H20N2O5 | 50 MG
DBCO-NHS ester 3 is an amine-reactive dibenzylcyclooctyne (DBCO) N-hydroxysuccinimide (NHS) ester used for copper-free click chemistry and as a linker in antibody-drug conjugate and bioconjugation workflows. It reacts with primary amines to install a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners.
- Amine-reactive NHS ester for efficient conjugation to primary amines.
- Facilitates copper-free strain-promoted alkyne-azide cycloaddition (SPAAC).
- Suitable for use as a linker in antibody-drug conjugate and bioconjugation workflows.
- Supplied as a white to off-white solid, compatible with low-temperature storage.
- Typical purity around 95.6% and molecular weight 416.43 g/mol support reliable reaction performance.
Medchemexpress LLC Ccnd3 protein, human (biotinylated, MBP, His, Flag) | >85.0% | 50UG
Recombinant human cyclin D3 (CCND3) is supplied as a biotinylated, affinity-tagged protein spanning amino acids M1-L292. The product is expressed in E. coli and formulated for research applications including binding assays, pull-downs, and antibody validation; consult the SDS/COA for storage and handling information.
- Biotinylated for streptavidin capture and sensitive detection.
- N-terminal MBP tag to enhance solubility and facilitate purification.
- C-terminal 6xHis and Flag tags for affinity purification and versatile detection.
- Full-length human sequence (M1-L292) preserves native epitopes.
- Expressed in E. coli for reproducible recombinant production.
- Purity greater than 85% as determined by reducing SDS-PAGE.
- Available in small research sizes suitable for assay development.
Apexbio Technology LLC Biotin-16-dUTP(Synonyms: Biotin-16-2'-deoxyuridine-5'-triphosphate, Biotin-16-dUTP nucleotide), 200ul (5 mM).
Biotin-16-dUTP is a biotin-labeled nucleotide analog utilized extensively in biomedical research for nucleic acid modification and detection Structurally modified to contain a biotin moiety linked via a 16-carbon spacer this compound functions by enzymatic incorporation into DNA strands mediated by DNA polymerases Following integration the biotin group serves as an affinity tag enabling subsequent detection through biotin-binding proteins such as streptavidin Applications include DNA labeling techniques in fluorescence microscopy and flow cytometry facilitating the visualization and analysis of nucleic acids in vitro
Medchemexpress LLC 3aS 4S 6aR -Biotin- 100mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202473.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 250 MG
Bis-PEG1-NHS ester is a short, non-cleavable polyethylene glycol (PEG) homobifunctional linker bearing N-hydroxysuccinimide (NHS) ester groups, supplied as a white to off-white solid for research use. It is designed for antibody-agent conjugation and other amine-targeted bioconjugation applications where a hydrophilic, short spacer is required.
- non-cleavable, homobifunctional PEG linker with NHS ester termini
- short 1-unit PEG spacer to increase hydrophilicity and solubility
- amine-reactive NHS esters for labeling primary amines on proteins and peptides
- supplied as a solid with recommended storage at -20°C for long term
- batch-specific purity reported by COA; suitable for research applications only
eMolecules 1688598-83-5 | Ambeed | Bis(25-dioxopyrrolidin-1-yl) (disulfanediylbis(ethane-21-diyl)) dicarbonate | 100mg | 571782781 | A1192322 | 436.41 | C14H16N2O10S2
Ambeed | (4R5R)-45-Diphenyl-2-(quinolin-2-yl)-45-dihydrooxazole | 250mg | 627733199 | A1350006 | 2417321-38-9 | 350.421 | C24H18N2O
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OC(C)(C)C)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 117565039](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502191168.JPG-250.jpg)
eMolecules 2488-18-8 | Boc-met-onp | Combi-Blocks | MFCD00038123 | 370.420 | C16H22N2O6S | 98.000 | CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 117565039
Boc-met-onp | Combi-Blocks | 2488-18-8 | MFCD00038123 | 370.420 | C16H22N2O6S | 98.000 | CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)Oc1ccc(cc1)[N+]([O-])=O | 1g | 117565039
Medchemexpress LLC Azido-PEG9-NHS ester | 2801772-87-0 | C25H44N4O13 | 25 MG
Azido-PEG9-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent with an azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. It also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Target PROTAC linkers
- Used in PROTAC pathway
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Medchemexpress LLC Nhs-PEG2-SS-PEG2-NHS | 580.63 | C22H32N2O12S2 | 50 MG
NHS-PEG2-SS-PEG2-NHS is a cleavable, homobifunctional polyethylene glycol (PEG) linker containing a central disulfide bond and two N-hydroxysuccinimide (NHS) activated esters. It is intended for bioconjugation and use as an antibody-drug conjugate (ADC) linker in research settings.
- Molecular formula: C22H32N2O12S2.
- Molecular weight: 580.63.
- Contains a reducible disulfide (cleavable) linker between PEG2 units.
- Homobifunctional with two NHS activated esters for amine coupling.
- Supplied in small laboratory quantity suitable for research use.
- Storage: store sealed at -20°C, protect from moisture; in solution, recommended storage at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Biotin-PEG8-acid | 2143964-62-7 | 99.8% | C29H53N3O12S | 50 MG
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Appears as a white to off-white solid
- Molecular weight: 667.81
Medchemexpress LLC Azido-PEG9-NHS ester | 2801772-87-0 | >98% | C25H44N4O13 | 50 MG
Azido-PEG9-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. For optimal stability, store in a tightly sealed container in a cool, well-ventilated area, away from direct sunlight and ignition sources.
- Can be used in the synthesis of PROTACs
- Features an Azide group for click chemistry applications
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
- Recommended storage at -20°C for up to 3 years in pure form
Medchemexpress LLC KAT6A protein, human (biotinylated, Avi) | 93.5% | 10UG
KAT6A Protein, Human (Biotinylated, Avi) is a recombinant fragment of the human histone acetyltransferase KAT6A (residues G497-I780), expressed in E. coli and N-terminally labeled with an Avi biotinylation tag. The material is provided at microgram scale for research use, characterized by reducing SDS-PAGE, and has an expected molecular weight of approximately 35.6 kDa.
- Biotinylated via Avi tag for streptavidin-based capture and detection.
- Suitable for protein-protein interaction and binding assays.
- Purity greater than 90% as determined by reducing SDS-PAGE.
- Recombinantly expressed in E. coli for scalable production.
- Covers the KAT6A domain G497-I780 for domain-specific studies.
- Supplied in microgram quantities for biochemical and biophysical assays.